教育经历
2007-2010 华中科技大学，博士
2005-2007 华中科技大学，硕士
2001-2005 东北大学, 本科
工作经历
2022-至今 伟德国际1946官方网生命科学中心，研究员
2010-2022 哈佛医学院和波士顿儿童医院，博士后，讲师
研究方向
肠道干细胞和肠癌的微环境调控：利用类器官（organoid）模型和高通量CRISPR/Cas9遗传筛选平台，以小鼠为模式动物研究（1）干细胞通路（如Wnt信号通路）的分子机制及其在肠道干细胞和肠癌微环境调控中的作用；（2）肠道屏障在生理和病理（如肠癌）条件下的上皮细胞和间充质细胞、免疫细胞等的相互作用。
论文发表
1. Yiwei Li*, Maorong Chen*, Jiliang Hu, Ren Sheng, Qirong Lin, Xi He, Ming Guo. Volumetric compression induces intracellular crowding to control intestinal organoid growth via Wnt/β-catenin signaling. Cell Stem Cell. 2021 Jan 7;28(1):63-78.e7. doi: 10.1016/j.stem.2020.09.012.
2. Maorong Chen*, Nathalia Amado*, Jieqiong Tan, Alice Reis, Mengxu Ge, Jose Garcia Abreu, Xi He. TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis. Elife. 2020 Sep 14;9:e56793. doi:10.7554/eLife.56793.
3. Wenzhe Ma*, Maorong Chen*, Hong Kang, Zachary Steinhart, Stephane Angers, Xi He, Marc W Kirschner. Single molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16690-16701.
4. Yiwei Li, Angelo S Mao, Bo Ri Seo, Xing Zhao, Satish Kumar Gupta, Maorong Chen, Yu Long Han, Ting-Yu Shih, David J Mooney, Ming Guo. Compression-induced dedifferentiation of adipocytes promotes tumor progression. Sci Adv. 2020 Jan 22;6(4):eaax5611.
5. Maorong Chen*, Xi He. APC Deficiency Leads to ß-Catenin Stabilization and Signaling Independent of LRP5/6. Dev Cell. 2019 Jun 17; 49(6):825-826.
6. Yanpeng Ci, Xiaoming Li, Maorong Chen, Jiateng Zhong, Brian J. North, Hiroyuki Inuzuka, Xi He, Yu Li, Jianping Guo, Xiangpeng Dai. SCFβ-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation. Protein Cell. 2018 Oct;9(10):879-889.
7. Matthias, Zebisch, Yang Xu, Christos Krastev, Bryan T Macdonald, Maorong Chen, Robert JC Gilbert, Xi He, E Yvonne Jones. Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin. Nat Commun. 2013 Nov 14;4:2787.
8. Jingjing Wang, Zhaoyu Li, Zijing Xu, Liang Hua, Xiaojun Feng, Maorong Chen, Wei Du, Zhengxing Wu, Qingming Luo, Tao Xu, Bi-Feng Liu. Development of an integrated microfluidic device for evaluating of in vivo chemo-sensing of intact Caenorhabditis elegans. Sensors and Actuators B: Chemical. Volume 178, 1 March 2013, Pages 343–349.
9. Xian Wang, Dangfeng Wang, Pan Jing, Yuangan Wu, Yanzhi Xia, Maorong Chen, Lin Hong. A novel Golgi retention signal RPWS for tumor suppressor UBIAD1. PLoS One. 2013 Aug 19;8(8):e72015.
10. Xiang-Guang Lin*, Min Ming*, Mao-Rong Chen*, Wei-Pin Niu, Yong-Deng Zhang, Bei Liu, Ya-Ming Jiu, Jun-Wei Yu, Tao Xu, Zheng-Xing Wu. UNC-31/CAPS docks and primes dense core vesicles in C. elegans neurons. Biochem Biophys Res Commun. 2010 Jul 2;397(3):526-31.
11. Mao-Rong Chen*, Song Yang*, Wei-Pin Niu, Zhao-Yu Li, Ling-Feng Meng, Zheng-Xing Wu. A novel fluorescent timer based on bicistronic expression strategy in Caenorhabditis elegans. Biochem Biophys Res Commun. 2010 Apr 23;395(1):82-6.
12. Geliang Gan, Hong Yi, Maorong Chen, Liang Sun, Wenxin Li, Yingliang Wu, Jiuping Ding. Structural basis for toxin resistance of beta4-associated calcium-activated potassium (BK) channels. J Biol Chem. 2008 Aug 29;283(35): 24177-84.
13. Zhi-Tao Hu*, Mao-Rong Chen*, Zhao Ping, Yong-Ming Dong, Rong-Ying Zhang, Tao Xu, Zheng-Xing Wu. Synaptotagmin IV regulates dense core vesicle (DCV) release in LbetaT2 cells. Biochem Biophys Res Commun. 2008 Jul 11;371(4):781-6.
14. Maorong Chen*, Geliang Gan*, Ying Wu, Lu Wang, Yingliang Wu, Jiuping Ding. Lysine-rich extracellular rings formed by hbeta2 subunits confer the outward rectification of BK channels. PLoS One. 2008 May 7;3(5):e2114.
15. Caixia Lv*, Maorong Chen*, Geliang Gan*, Lifen Wang, Tao Xu, Jiuping Ding. Four-turn alpha-helical segment prevents surface expression of the auxiliary hbeta2 subunit of BK-type channel. J Biol Chem. 2008 Feb 1;283(5):2709-15.
*第一或共同第一作者
本实验室长期招聘博士后和助理研究员,欢迎加入我们的团队。E-mail: mrchen@ynu.edu.cn
