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栏目导航

赵沛基


研究员/ pjzhao@ynu.edu.cn /微生物学

个人简历

1. 1993.09 ~ 1997.07伟德国际1946官方网生物系生物技术专业，获理学学士学位；

2. 2001.09 ~ 2004.07 中国科学院昆明植物研究所，获理学硕士学位；

3. 2005.09 ~ 2008.07中国科学院昆明植物研究所，获理学博士学位；

4. 1997.07 ~ 2003.07 中国科学院昆明植物研究所，研究实习员；

5. 2003.07 ~ 2007.12中国科学院昆明植物研究所，助理研究员；

6. 2008.01 ~ 2016.04 中国科学院昆明植物研究所，副研究员；

7. 2012.09 ~ 2013.03 美国The University of Nebraska–Lincoln化学系, 访问学者；

8. 2009.01硕士研究生导师；

9. 2016.5 ~ 2016.11, 伟德国际1946官方网省部共建云南生物资源保护与利用国家重点实验室，副研究员；

10.  2016.12 ~ 至今, 伟德国际1946官方网省部共建云南生物资源保护与利用国家重点实验室，研究员


主要研究方向

围绕“微生物代谢产物生物合成”研究方向，运用天然产物化学、生化与分子生物学等学科知识与实验技术，开展微生物次生代谢产物的发现、生物合成及其调控机制的研究：

1. 微生物来源活性天然产物的分离鉴定；

2. 活性天然产物的生物合成。


主要论文

  1. Pei-Ji Zhao*, Yan-Long Yang, Liangchen Du, Ji-Kai Liu, Ying Zeng*. Elucidating the biosynthetic pathway for vibralactone, a novel pancreatic lipase inhibitor with a fused bicyclic β-lactone. Angewandte Chemie - International Edition. 2013, 52 (8): 2298-2302.

  2. Yan Lia, Pei-Ji Zhaoa,(aCo-author) Qian-Jin Kang, Juan Ma, Lin-Quan Bai*, Zi-Xin Deng. Dual carbamoylations on the polyketide and glycosyl moiety by Asm21 result in extended ansamitocin biosynthesis.Chemistry & Biology. 2011, 18 (12): 1571-1580.  

  3. Peiji Zhao, Linquan Bai*, Juan Ma, Ying Zeng, Lei Li, Yirong Zhang, Chunhua Lu, Huanqin Dai, Zhaoxian Wu, Yaoyao Li, Xuan Wu, Gang Chen, Xiaojiang Hao, Yuemao Shen*, Zixin Deng, Heinz G. Floss. Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins. Chemistry & Biology. 2008, 15, 863-874.

  4. Yin-He Yang, Xiao-Li Fu, Liang-Qun Li, Ying Zeng, Cheng-Yun Li, Yi-Neng He, Pei-Ji Zhao*. Naphthomycins L−N, Ansamycin Antibiotics from Streptomyces sp. CS. Journal of Natural Products. 2012, 75, 1409-1413.

  5. Pei-Ji Zhao, Suo Gao, Li-Ming Fan, Jing-Lei Nie, Hong-Ping He, Ying Zeng, Yue-Mao Shen, Xiao-Jiang Hao*. Approach to the Biosynthesis of Atisine-type Diterpenoid Alkaloids.Journal of Natural Products.2009, 72(4): 645-659.

  6. Fei-Xue Yu, Zhe Li, Yao Chen, Yin-He Yang, Guo-Hong Li, Pei-Ji Zhao*. Four new steroids from the endophytic fungus Chaetomium sp. M453 derived of Chinese herbal medicine Huperzia serrata. Fitoterapia, 2017,117: 41–46.

  7. Fei-Xue Yu, Yao Chen, Yin-He Yang, Pei-Ji Zhao*. Four new dimeric spiro-azaplilone derivatives cochliodones E-H from the entophytic fungus Chaetomium sp. M336. Phytochemistry Letters, 2016, 16, 263-267.

  8. Jing Li, Jin Xie, Yin-He Yang, Xiao-Lian Li, Ying Zeng, Pei-Ji Zhao*. Pestalpolyols A–D, cytotoxic polyketides from Pestalotiopsis sp. cr013. Planta Medica, 2015, 81: 1285-1289.

  9. Yan-Mei Chen, Yin-He Yang, Xiao-Nian Li, Cheng Zou and Pei-Ji Zhao*. Diterpenoids from the Endophytic Fungus Botryosphaeria sp. P483 of the Chinese Herbal Medicine Huperzia serrate. Molecules. 2015, 20, 16924-16932.

  10. Jin Xie, Jing Li, Yin-He Yang, Yu-Hui Chen, Pei-Ji Zhao*. Two new ambuic acid analogs from Pestalotiopsis sp. cr013. Phytochemistry Letters, 2014, 10: 291-294.

  11. Juan Ma, Yue-Mao Shen, Ying Zeng, Pei-Ji Zhao*. Two New N-(O-Carbamoylglucopyranosyl)-N- dimethylansamitocins from Actinosynnema pretiosum. Helvetica Chimica Acta. 2012, 95(9):1630–1636.

  12. Jun-Tian Li, Xiao-Li Fu, Chun Tan, Ying Zeng, Qi Wang，Pei-Ji Zhao*. Two new chroman derivations from endophytic Penicillium sp. DCS523. Molecules. 2011, 16, 686-693.

  13. Xiao-Mei Zhang, Guo-Hong Li, Juan Ma, Ying Zeng, Wei-Guang Ma, Pei-Ji Zhao*. Endophytic fungus Trichothecium roseum LZ93 antagonizing pathogenic fungi In Vitro and its secondary metabolites. Journal of Microbiology. 2010, 48(6): 784-790.